詹伊琳 副教授
學 歷
2002.08～2008.10 國防醫學院生命科學研究所/博士
1999.09～2000.10 英國曼徹斯特大學/免疫及免疫遺傳學/碩士
1993.09～1997.06 高雄醫學大學/醫學技術系/學士
專 長
微生物學、微生物遺傳、細胞生物學、病毒學
經 歷
2019.08~迄今 中國文化大學生命科學系 副教授
2015.01~2019.07 中國文化大學生命科學系 助理教授
2012.07～2015.01 國防醫學院貴重儀器中心研究員/組長；兼任助理教授；國際交流事務組
2011.08～2012.06 三軍總醫院血管轉譯醫學研究室/博士後研究員
2009.01～2011.06 中央研究院生物醫學研究所/博士後研究員
2001.01～2002.04 財團法人食品工業發展研究所/副研究員
1998.07～1999.07 中央研究院生物醫學研究所/研究助理
開授課程
細胞生物學、免疫學、病毒學、生命科學
專業證照
醫事檢驗師執照 (台檢驗字第8999號)
研究室
大義館413 (電話) 02-2861-0511＃26211
Email：zyl13@ulive.pccu.edu.tw
研究方向
1. 病毒感染小鼠動物模式探討藻類萃取物對登革熱病毒的影響
2. 利用結腸癌小鼠模式探討硒化合物對於結腸癌腫瘤生長及腫瘤相關巨噬細胞分化之影響
著 作
期刊論文
Kao, Y. R., Shih, J. Y., Wen, W. C., Ko, Y. P., Chen, B. M., Chan, Y. L., Chu, Y. W., Yang, P. C., Wu, C. W., and Roffler, S. R. Tumor-associated antigen L6 and the invasion of human lung cancer cells. Clinical Cancer Res, 9: 2807-2816, 2003. (SCI: 8.193, 13/202)
Wu, C. J., Huang, H. W., Liu, C. Y., Hong, C. F., and Chan, Y. L. Inhibition of SARS-CoV replication by siRNA. Antiviral Res, 65: 45-48, 2005. (SCI: 3.434, 58/254)
Wu, C. J. and Chan. Y. L. Coronaviruses and severe acute respiratory syndrome associated coronavirus (SARS-CoV). In: Hefferon, K.L. (Eds.), Recent advances in RNA virus replication, first ed. Transworld research network, Kerala, India, pp. 29-44, 2006.
Wu, C. J. and Chan, Y. L. Antiviral applications of RNAi for coronavirus. Expert Opin Investig Drugs, 15: 89-97, 2006. (SCI: 5.432, 18/254)
Wu, C. J., Li, T. L., Huang, H. W., Tao, M. H., and Chan, Y. L. Development of an effective Japanese encephalitis virus-specific DNA vaccine. Microbes Infect, 8: 2578-2586, 2006. (SCI: 2.731, 49/119)
Chan, Y. L., Chang, T. H., Liao, C. L., and Lin, Y. L. The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. Journal of Virolology, 82: 10455-10464, 2008. (SCI: 4.648, 7/32)
Cheng, J. Y., Huang, H. N., Tseng, W. C., Li, T. L., Chan, Y. L., Cheng, K. C., and Wu, C. J. Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection. Journal of Controlled Release, 135: 242-249, 2009. (SCI: 7.261, 11/254)
Huang, H. N., Li, T. L., Chan, Y. L., Chen, C. L., and Wu, C. J. Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus. Biomaterials, 30: 6017-6025, 2009. (SCI: 8.312, 1/32)
Chai, H. J., Li, J. H., Huang, H. N., Li, T. L., Chan, Y. L., Shiau, C. Y., and Wu, C. J. Effects of sizes and conformations of fish scale collagen peptides (FSCPs) on facial skin qualities and transdermal penetration efficiency. Journal of Biomedicine and Biotechnology. Article ID 757301, 9 pages, 2010. (SCI: 2.706, 53/165)
Hwang, P. A., Chien, S. Y., Chan, Y. L., Lu, M. K., Kong, Z. L., Wu, C. H., and Wu, C. J. Inhibition of LPS-induced Inflammatory Responses by Sargassum hemiphyllum sulfated polysaccharide extract in RAW 264.7 Macrophage Cells. Journal of Agricultural and Food Chemistry, 59: 2062-2068, 2011. (SCI: 3.107, 2/56)
Huang, H. N., Pan, C. Y., Rajanbabu, V., Chan, Y. L., Wu, C. J., and Chen, J. Y. Modulation of immune responses by the antimicrobial peptide, epinecidin (Epi)-1, and establishment of an Epi-1-based inactivated vaccine. Biomaterials, 32: 3627-3636, 2011. (SCI: 8.312, 1/32)
Wu, C. J., Wang, H., Chan, Y. L., and Li, T. L. Passive immune-protection of small abalone against Vibrio alginolyticus infection by anti-Vibrio IgY-encapsulated feed. Fish & Shellfish Immunology, 30: 1042-1048, 2011. (SCI: 3.034, 3/129)
Wang, H., Lai, Y.J., Chan, Y.L., Li, T.L., and Wu, C. J. Epigallocatechin -3- gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia. Cancer Letters, 305: 40-49, 2011. (SCI: 5.016, 33/202)
Huang, H. N., Rajanbabu, V., Pan, C. Y., Chan, Y. L., Chen, J. Y., and Wu, C. J. Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5. Biomaterials, 32: 6804-6814, 2011. (SCI: 8.312, 1/32)
Chai, H. J., Chan, Y. L., Li, T. L., Chen, Y. C., Wu, C. H., Shiau, C. Y., and Wu, C. J. Composition characterization of Myctophids (Benthosema pterotum): antioxidation and safety evaluations for Myctophids protein hydrolysates. Food Research International, 46:118-126, 2012. (SCI: 3.050, 14/123)
Wang, H.*, Chan, Y. L.*, Li, T. L., and Wu, C. J. Improving cachectic symptoms and immune strength of tumor-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang. European Journal of Cancer, 48:1074-1084, 2012. (*equal contribution, SCI: 4.819, 41/202)
Chiu, Y. H.*, Chan, Y. L.*, Li, T. L., and Wu, C. J. Inhibition of Japanese encephalitis virus infection by the sulfated polysaccharide extracts from Ulva lactuca. Marine Biotechnology. 14:468-478, 2012. (SCI: 3.152, 8/102)
Chiu, Y. H.*, Chan, Y. L.*, Tsai, L. W., Li, T. L., and Wu, C. J. Prevention of human enterovirus 71 infection by kappa carrageenan. Antiviral Research, 95: 128-134, 2012. (* equal contribution, SCI: 3.434, 58/254)
Wang, H.*, Chan, Y. L.*, Li, T. L., Bauer, B. A., Hsia, S., Wang, C. H., Huang, J. S., Wang, H. M., Yeh, K. Y., Huang, T. H, Wu, G. J., and Wu, C. J. Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast. PLoS One, 8:e52912, 2013. doi:10.1371/journal.pone.0052912. (*equal contribution, SCI: 3.534, 8/55)
Huang, H. N., Rajanbabu, V., Pan, C. Y., Chan, Y. L., Wu, C. J., and Chen, J. Y. A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors. Biomaterials, 34: 10151-10159, 2013. (SCI: 8.312, 1/32)
Huang, H. N., Rajanbabu, V., Pan, C. Y., Chan, Y. L., Wu, C. J., and Chen, J. Y. Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Biomaterials, 34: 10319-10327, 2013. (SCI: 8.312, 1/32)
Chai, H. J., Chan, Y. L., Li, T. L., Shiau, C. Y., and Wu, C. J. Evaluation of lanternfish (Benthosema pterotum) hydrolysates as antioxidants against hydrogen peroxide induced oxidative injury. Food Research International, 54: 1409-1418, 2013. (SCI: 3.050, 14/123)
Huang, H. N., Pan, C. Y., Chan, Y. L., Chen, J. Y., and Wu, C. J. Use of the antimicrobial peptide pardaxin (GE33) to protect against MRSA infection in mice with skin injuries. Antimicrobial Agents and Chemotherapy, 58: 1538-1545, 2014. (SCI: 4.451, 27/254)
Chen, C. C., Hsieh, D. S., Huang, K. J., Chan, Y. L., Hong, P. D., Yeh, M. K., and Wu, C. J. Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells. Drug Design, Development and Therapy, 8: 459-474, 2014. (SCI: 3.026, 75/254)
Yang, S.M., Chan, Y.L., Hua, K.F., Chang, J.M., Chen, H.L., Tsai, Y.J., Hsu, Y.J., Chao, L.K., Feng-Ling, Y., Tsai, Y.L., Wu, S.H., Wang, Y.F., Tsai, C.L., Chen, A., Ka, S.M.. Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis. Free Radical Biology and Medicine, 73: 260-269, 2014. (SCI: 5.271, 17/122)
學位論文
博士論文：抗病毒蛋白Viperin基因表現調節及其抗病毒作用之研究（Study of the gene expression regulation and anti-viral function of Viperin）
碩士論文：Characterization of the intracellular interactions of the 5T4 oncofotal antigen
研討會發表(Conference presentation)
專書、委託報告與研討會全文(Book sections, technical reports & conference articles)
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