分 子 遺 傳 研 究 室 Molecular Genetics Laboratory

吳賜猛 (Shy-Meeng Wu) 教授 / 系主任

 

學　　歷：

1999.8~2003.6 長庚大學基礎醫學研究所 博士

1990.8~1992.6 中國文化大學生物技術研究所 碩士

1986.9~1990.6 中國文化大學植物學系 學士

 

專　　長：

細胞生物學、分子遺傳學、蛋白質體學

 

經　　歷：

2017~迄今 中國文化大學生命科學系 系主任

2017~迄今 中國文化大學生命科學系 教授

2012~2017 中國文化大學生命科學系 副教授

2009~2012 中國文化大學生命科學系 助理教授

2004-2009 中國文化大學生命科學系 兼任助理教授

2005-2009 財團法人佛教慈濟綜合醫院台分院 助理研究員

 

開授課程：

普通生物學、分子生物學、生物技術、基因體學、生物技術特論、蛋白質體學

 

目前研究主題：

1. 探討肝癌幹細胞的特徵與抗癌藥物的篩選平台開發

2. 探討山苦瓜中活性成分對肝癌幹細胞之影響

3. 探討山苦瓜中活性成分對代謝症候群之改善效應

4. 中醫藥材對減緩大白鼠中風之療效探討

5. 結合類神經網絡之深度學習來尋找新的腫瘤生物標記

 

Email：wsm4@ulive.pccu.edu.tw

 

著 作：

Wu S, Hsu LA, Teng MS, Chou HH, Ko YL. Differential Genetic and Epigenetic Effects of the KLF14 Gene on Body Shape Indices and Metabolic Traits. Int J Mol Sci. 2022 Apr; 23(8): 4165.

Hsu LA, Teng MS, Wu S, Chou HH, Ko YL. Common and Rare PCSK9 Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study. Int J Mol Sci. 2022 Sep; 23(18): 10418.

Yeh KH, Hsu LA, Teng MS, Wu S, Chou HH, Ko YL. Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits. Genes (Basel) 2022 Mar; 13(3): 491.

Wu S, Huang C, Chen YR, Huang HC, Huang WC, Lai YH. Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation. Journal of Functional Foods 2021, 87, 104857.

Teng MS, Wu S, Hsu LA, Chou HH, Ko YL. Pleiotropic Effects of Functional MUC1 Variants on Cardiometabolic, Renal, and Hematological Traits in the Taiwanese Population. Int J Mol Sci. 2021 Oct; 22(19): 10641.

Chang CH, Wu S, Hsu KC, Huang WJ, Chen JJ. Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortune. Int J Mol Sci. 2021 Jul; 22(14): 7448.

Er LK, Wu S Cheng T, Ko YL, Teng MS. Genome-Wide Association Study on Adiponectin-Mediated Suppression of HDL-C Levels in Taiwanese Individuals Identifies Functional Haplotypes in CDH13. Genes (Basel) 2021 Oct; 12(10): 1582.

Liao YH, Er LK, Wu S, Ko YL, Teng MS. Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. Genes (Basel) 2021 Feb; 12(2): 148.

Wu S, Tseng IC, Huang WC, Su CW, Lai YH, Lin C, Lee AYL, Kuo CY, Su LY, Lee MC, Hsu TC, Yu CH. Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells. Cancers (Basel) 2020 Dec; 12(12): 3721.

Lai YH, Chen WN, Hsu TC, Lin C, Tsao Y, Wu S. Overall survival prediction of non-small cell lung cancer by integrating microarray and clinical data with deep learning. Sci Rep. 2020; 10: 4679

Duan DM, Jhang JY, Wu S, Teng MS, Hsu LA, Ko YL. Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women. Mol Genet Genomic Med. 2020 Jan 8:e1113.

Lin JF, Wu S, Juang JJ, Chiang FT, Hsu LA, Teng MS, Cheng ST, Huang HL, Ko YL. Osteoprotegerin and osteopontin levels, but not gene polymorphisms, predict mortality in cardiovascular diseases. Biomark Med. 2019 Jun;13(9):751-760.

Teng MS, Wu S, Hsu LA, Tzeng IS, Chou HH, Su CW, Ko YL. Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population. Lipids Health Dis. 2019 May 10;18(1):111.

Er LK, Hsu LA, Juang JJ, Chiang FT, Teng MS, Tzeng IS, Wu S, Lin JF, Ko YL. Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease. Int J Mol Sci. 2019 Mar 7;20(5). pii: E1174.

Lai YH, Liu HY, Huang CY, Chau YP, Wu S. Mitochondrial?DNA?associated TLR9 signalling is a potential serological biomarker for non?small cell lung cancer. Oncol Rep. 2019 Feb;41(2):999-1006.

Chen SW, Chu Y, Wu VC, Tsai FC, Nan YY, Lee HF, Chang CH, Chu PH, Wu S, Lin PJ. Microenvironment of saphenous vein graft preservation prior to coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2019 Jan 1;28(1):71-78.

Teng MS, Wu S, Er LK, Hsu LA, Chou HH, Ko YL. LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels. Diabetol Metab Syndr. 2018 Nov 6;10:79.

Er LK, Wu S, Hsu LA, Teng MS, Sun YC, Ko YL. Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases. Mediators Inflamm. 2018 Mar 12;2018:4670521.

Er LK, Teng MS, Wu S, Hsu LA, Tzeng IS, Cheng CF, Chang HI, Chou HH, Ko YL. Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese. Ci Ji Yi Xue Za Zhi. 2018 Jan-Mar;30(1):29-36.

Chu Y, Lai YH, Lee MC, Yeh YJ, Wu YK, Tsao W, Huang CY, Wu S. Calsyntenin-1, clusterin and neutrophil gelatinase-associated lipocalin are candidate serological biomarkers for lung adenocarcinoma. Oncotarget. 2017 Nov 14;8(64):107964-107976.

Teng MS, Hsu LA, Juan SH, Lin WC, Lee MC, Su CW, Wu S, Ko YL. A GDF15 3' UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p. PLoS One. 2017 Aug 14;12(8):e0183187.

Hsu LA, Wu S, Juang JJ, Chiang FT, Teng MS, Lin JF, Huang HL, Ko YL. Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors. Mediators Inflamm. 2017;2017:9398401.

Lin JF, Wu S, Juang JJ, Chiang FT, Hsu LA, Teng MS, Cheng ST, Huang HL, Sun YC, Liu PY, Ko YL. IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease. Atherosclerosis. 2017 Feb;257:71-77.

Wu S, Teng MS, Er LK, Hsiao WY, Hsu LA, Yeh CH, Lin JF, Lin YY, Su CW, Ko YL. Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese. PLoS One. 2017 Jan 17;12(1):e0169516.

Cheng ST, Wu S, Su CW, Teng MS, Hsu LA, Ko YL. Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population. J Formos Med Assoc. 2017 Jan;116(1):18-23.

Chang YK, Lai YH, Chu Y, Lee MC, Huang CY, Wu S. Haptoglobin is a serological biomarker for adenocarcinoma lung cancer by using the ProteomeLab PF2D combined with mass spectrometry. Am J Cancer Res. 2016 Aug 1;6(8):1828-36.

Lin JF, Hsu SY, Teng MS, Wu S, Hsieh CA, Jang SJ, Liu CJ, Huang HL, Ko YL. Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction. Acta Cardiol Sin. 2016 Jul;32(4):420-7.

Ko YL, Hsu LA, Wu S, Teng MS, Chou HH. CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects. Mediators Inflamm. 2016; 2016:5830361.

Wu S, Hsu LA, Teng MS, Lin JF, Chou HH, Lee MC, Wu YM, Su CW, Ko YL. Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population. Lipids Health Dis. 2016 May 13;15:94.

Wu CC, Tsai FM, Chen ML, Wu S, Lee MC, Tsai TC, Wang LK, Wang CH. Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors. Biomed Res Int. 2016;2016:2532371.

Er LK, Wu S, Chou HH, Hsu LA, Teng MS, Sun YC, Ko YL. Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals. PLoS One. 2016 Mar 1;11(3):e0149731.

Ho YT, Wu S, Cheng CF, Hsu LA, Teng MS, Yeh CH, Lin JF, Ko YL. Effects of obesity on the association between common variations in the TBX5 gene and matrix metalloproteinase 9 levels in Taiwanese. Ci Ji Yi Xue Za Zhi. 2016 Jan-Mar;28(1):9-14.

Lin JF, Hsu SY, Wu S, Teng MS, Chou HH, Cheng ST, Wu TY, Ko YL. QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. Int J Med Sci. 2015 Nov 17;12(12):968-73.

Teng MS, Wu S, Hsu LA, Chou HH, Ko YL. Differential Associations between CDH13 Genotypes, Adiponectin Levels, and Circulating Levels of Cellular Adhesive Molecules. Mediators Inflamm. 2015;2015:635751.

Teng MS, Hsu LA, Wu S, Sun YC, Juan SH, Ko YL. Association of CDH13 genotypes/haplotypes with circulating adiponectin levels, metabolic syndrome, and related metabolic phenotypes: the role of the suppression effect. PLoS One. 2015 Apr 13;10(4):e0122664

Duan DM, Wu S, Hsu LA, Teng MS, Lin JF, Sun YC, Cheng CF, Ko YL*. Associations between TRPV4 haplotypes and body mass index in Taiwanese subjects. Mol Genet Genomics. 2015 Aug;290(4):1357-65.

Wu S, Hsu LA, Cheng ST, Teng MS, Yeh CH, Sun YC, Huang HL, Ko YL*. Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease. Int J Mol Sci. 2014 Dec 4;15(12):22421-37.

Chou HH, Hsu LA, Wu S, Teng MS, Sun YC, Ko YL*. Leptin-to-adiponectin ratio is related to low grade inflammation and insulin resistance independent of obesity in non-diabetic Taiwanese: a cross-sectional cohort study. Acta Cardiolgica Sinica.2014, 30(3) :204-214.

Lin JF, Wu S, Hsu SY, Yeh KH, Chou HH, Cheng ST, Wu TY, Hsu WT, Yang CC, Ko YL*. Growth-differentiation factor-15 and major cardiac events. Am J Med Sci. 2014 Apr;347(4):305-11.

Huang HL, Wu S, Hsu LA, Teng MS, Lin JF, Sun YC, Ko YL*, Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity. BMC Med Genet. 2013 Mar 4; 14:30

Chen ML, Wu S, Tsai TC, Wang LK, Tsai FM. Regulation of macrophage immune responses by antipsychotic drugs. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):573-80. (SCI )

Teng MS, Hsu LA, Wu S, Chou HH, Chang CJ, Sun YZ, Juan SH, Ko YL. Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level.  Atherosclerosis. 2013 Jun;228(2):406-12. (SCI )

Lai CW, Sun TL, Lo W, Tang ZH, Wu S, Chang YJ, Wu CC, Yu SC, Dong CY, Chen LW. Shedding-induced gap formation contributes to gut barrier dysfunction in endotoxemia. J Trauma Acute Care Surg. 2013 Jan;74(1):203-13. (SCI )

Wu S, Hsu LA, Teng MS, Lin JF, Chang HH, Sun YC, Chen HP, Ko YL. Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level. BMC Med Genet. 2012 Nov 29;13:115. (SCI )

Shen EP, Tsay RY, Chia JS, Wu S, Lee JW, Hu FR. The role of type III secretion system and lens material on adhesion of Pseudomonas aeruginosa to contact lenses. Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6416-26. (SCI )

Peng YJ, Pan CY, Hsieh YT, Wu S, Chu HN, Hsu WC. The application of tissue engineering in reversing mitomycin C-induced ischemic conjunctiva. J Biomed Mater Res A. 2012 May;100(5):1126-35. (SCI )

Lin JF, Wu S, Huang SS, Lu BY, Lin SM, Tsai SK. Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction. Chin J Physiol. 2011 Dec 31;54(6):406-12. (SCI )

Hsieh CA, Ko YL, Hsu TS, Chang CJ, Teng MS, Wu S and Hsu LA. Angiotensin-I Converting Enzyme Gene Polymorphisms and the Risk of Venous Thromboembolism in an Ethnically Chinese Population Living in Taiwan. 2011 Acta Cardiol Sinica 27(4): 252-258.

Wu S, Hsu LA, Cheng CF, Teng MS, Chou HH, Lin H, Chang PY, Ko YL. Effect of obesity on the association between ATF3 gene haplotypes and C-reactive protein level in Taiwanese. Clin Chim Acta. 2011 May 12;412(11-12):1026-31. (SCI )

Hsu LA, Ko YL, Teng MS, Wu S, Chou HH, Chang PY, Chang HH. Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese. Clin Chim Acta. 2011 Apr 11;412(9-10):725-9. (SCI )

Lin JF, Hsu SY, Wu S, Liau CS, Chang HC, Liu CJ, Huang HL, Ho YT, Weng SL, Ko YL. Data feedback reduces door-to-balloon time in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2011 Jan;26(1):25-30. (SCI )

Hsu LA, Chang CJ, Wu S, Teng MS, Chou HH, Chang HH, Chang PY, Ko YL. Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects. Metabolism. 2010 Dec;59(12):1710-6. (SCI )

Wu S, Hsu LA, Chou HH, Teng MS, Chang HH, Yeh KH, Chen CC, Chang PY, Cheng CF, Ko YL. Association between an ASIC3 gene variant and insulin resistance in Taiwanese. Clin Chim Acta. 2010 Aug 5;411(15-16):1132-6. (SCI )

Wu S, Hsu LA, Teng MS, Lin JF, Chang HH, Chang PY, Hu CF, Ko YL. Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. Clin Chem Lab Med. 2010 Apr;48(4):543-9. (SCI )

Chou HH, Hsu LA, Liu CJ, Teng MS, Wu S, Ko YL. Insulin resistance is associated with C-reactive protein independent of abdominal obesity in nondiabetic Taiwanese. Metabolism. 2010 Jun;59(6):824-30. (SCI )

Hsu LA, Ko YL, Wu S, Teng MS, Chou HH, Chang CJ, Chang PY. Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese. Metabolism. 2009 Jul;58(7):983-8. (SCI )

Chang YK, Hwang JM, Chang CS, Wu S. Preliminary results of intensity-modulated radiotherapy in the treament of nasopharyngeal carcinoma. Therapeut Radiol Oncol. 2010 June; 12(2): 101-112.

Hsu, LA, Teng MS, Ko YL, Chang CJ, Wu S, Wang CL, Hu CF. The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan. Clin Chem Lab Med. 2009;47(2):154-8. ( SCI )

Hsu LA, Chang CJ, Teng MS, Wu S, Hu CF, Chang WY, Ko YL. CAG repeat polymorphism of the MEF2A gene is not associated with the risk of coronary artery disease among Taiwanese. Clin Appl Thromb Hemost. 2010 Jun;16(3):301-5. (SCI )

Teng MS, Hsu LA, Wu S, Chang HH, Chou HH, Ko YL. Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity. Atherosclerosis. 2009 Jun;204(2):e64-9. (SCI )

Hsu LA, Ko YL, Chang CJ, Teng MS, Wu S, Hu CF. Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan. Clin Chem Lab Med. 2008;46(12):1714-9. (SCI )

Ko YL, Hsu LA, Wu S, Teng MS, Chang HH, Chen CC, Cheng CF. Genetic variation in the ASIC3 gene influences blood pressure levels in Taiwanese. J Hypertens. 2008 Nov;26(11):2154-60. ( SCI )

Ko YL, Hsu LA, Hsu TS, Tsai CT, Teng MS, Wu S, Chang CJ, Lee YS. Functional polymorphisms of FGA, encoding alpha fibrinogen, are associated with susceptibility to venous thromboembolism in a Taiwanese population. Hum Genet. 2006 Mar;119(1-2):84-91. ( SCI )

Hsu LA, Ko YL, Chang CJ, Hu CF, Wu S, Teng MS, Wang CL, Ho WJ, Ko YS, Hsu TS, Lee YS. Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan. Atherosclerosis. 2006 Mar;185(1):143-9. ( SCI )

Ko YS, Yeh HI, Ko YL, Hsu YC, Chen CF, Wu S, Lee YS, Severs NJ. Three-dimensional reconstruction of the rabbit atrioventricular conduction axis by combining histological, desmin, and connexin mapping data. Circulation. 2004; 109: 1172-9. (SCI )

Hsu LA, Ko YL, Wu S, Teng MS, Peng TY, Chen CF, Chen CF, Lee YS. Association between a novel 11-base pair deletion mutation in the promoter region of the scavenger receptor class B type I gene and plasma HDL cholesterol levels in Taiwanese Chinese. Arterioscler Thromb Vasc Biol. 2003; 23:1869-74. ( SCI ; NSC-91–2314-B-182A-059)

Wu S, Ko YS, Teng MS, Ko YL, Hsu LA, Hsueh C, Chou YY, Liew CC, Lee YS. Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol. 2002; 34: 1595-607. (SCI; NSC 88-2314-B-182A-066, NSC 89-2314-B-182A-024 and NSC 89-2314-B-182A-158)

Lai LJ, Chen YF, Wu S, Tsao YP, Tsai RJ. Endothelial cell loss induced by phacoemulsification occurs through apoptosis. Chang Gung Med J. 2001 Oct;24(10):621-7.

Ko YL, Ko YS, Wu SM, Teng MS, Chen FR, Hsu TS, Chiang CW, Lee YS. Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese. Hum Genet. 1997 Sep;100(3-4):327-33. (SCI )

Ko YL, Hsu TS, Wu SM, Ko YS, Chang CJ, Wang SM, Chen WJ, Cheng NJ, Kuo CT, Chiang CW, Lee YS. The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals. Hum Genet. 1996 Aug;98(2):176-7. (SCI )

Lih CJ, Wu SM, Lin-Chao S. Rapid identification and isolation of transcriptionally active regions from mouse genomes. Gene. 1995 Oct 27;164(2):289-94. (SCI )